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The work introduces a method for diagnosing design flaws in object oriented systems, and finding meaningful refactorings to remove such flaws. The method is based on pairing up a structural pattern that is considered pathological (e.g. a code smell or anti-pattern) with a so called design context. The design context describes the design semantics associated to the pathological structure, and the desired strategic closure for that fragment. The process is tool supported and largely automated.

refactoring --- static analysis --- diagnosis --- restructuring --- design flaw

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De geneeskunde worstelt al eeuwen met het begrijpen en adequaat behandelen van ziekten die zich in het grensgebied tussen psyche en soma bevinden. Vooral aandoeningen zonder duidelijke lichamelijke verklaring - tegenwoordig 'functionele somatische syndromen' genoemd - zijn voor veel artsen en andere hulpverleners een doorn in het oog. Voorbeelden zijn: prikkelbaredarmsyndroom, chronische vermoeidheidssyndroom, fi bromyalgie ... De laatste jaren stapelen de bewijzen zich op dat het stresssysteem - de neurobiologische draaischijf tussen ons lichaam en ons brein - in deze ziekten een cruciale rol speelt. Dit boek geeft een up-to-date overzicht van deze nieuwe ontwikkelingen. Het is geschreven door een groep Leuvense psychiaters en psychologen, die allen klinisch en wetenschappelijk actief zijn op dit terrein. Naast verschillende stressgebonden ziektebeelden, komen ook meer algemene topics aan bod, zoals de rol van vroegkinderlijk trauma, het onderzoek naar prenatale stress, de link tussen stress, emoties en pijn, en de methodologische valkuilen van het stressonderzoek. De auteurs van dit boek hebben getracht deze complexe materie toegankelijk te maken voor een niet-gespecialiseerde lezer. Het boek is bedoeld voor artsen, psychologen en eenieder die geboeid is door de fascinerende vooruitgang van de moderne neurowetenschappen.

Psychosomatiek. --- Stress. --- stress --- Psychiatry --- Semiology. Diagnosis. Symptomatology --- Stress (Psychology) --- Medicine [Psychosomatic ] --- departement Gezondheidszorg 10 --- psychosomatiek --- Stress Stress --- Psychologie Psychologie --- Stress --- Neurologie (syndroom van Horner) --- Irritable bowel syndroom (spastisch colon) --- Chronisch vermoeidheidssyndroom --- Fibromyalgie --- Psychosomatiek --- Academic collection --- Psychosomatische stoornissen --- #KVHB:Stress --- #KVHB:Psychosomatiek --- 670 Gezondheid --- 604.6 --- psychosomatiek (gez) --- psychosomatische stoornissen (gez) --- stress (gez) --- psychosomatiek, psychologie van het ziek zijn, stress --- zelfhulp --- Psychosomatisch probleem --- psyche --- somatiek --- chronische ziekten

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""The Handbook"" is a detailed manual giving a step by step approach to undertaking the pharmacovigilance of antimalarials. It is intended to be a source of practical advice for pharmacovigilance centres. It provides information on spontaneous reporting of adverse drug reactions as a complement to other WHO publications. In addition, it provides details on how to conduct cohort event monitoring, which is a method of active safety surveillance collecting information on all adverse events occurring after treatment. It also details how to perform causality assessment and signal identification, ap

Adverse Drug Reaction Reporting Systems. --- Antimalarials -- standards. --- Antimalarials. --- Drug Monitoring. --- Drug Utilization Review -- methods. --- Pharmacoepidemiology -- methods. --- Product Surveillance, Postmarketing. --- Drug monitoring --- Antimalarials --- Drug Monitoring --- Drug Utilization Review --- Product Surveillance, Postmarketing --- Adverse Drug Reaction Reporting Systems --- Pharmacoepidemiology --- Methods --- Utilization Review --- Antiprotozoal Agents --- Investigative Techniques --- Drug Utilization --- Pharmacology --- Epidemiology --- Evaluation Studies as Topic --- Monitoring, Physiologic --- Quality of Health Care --- Quality Assurance, Health Care --- Public Health --- Health Occupations --- Biological Science Disciplines --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Diagnostic Techniques and Procedures --- Pharmacy Administration --- Antiparasitic Agents --- Disciplines and Occupations --- Medicine --- Health Services Administration --- Natural Science Disciplines --- Health Care Quality, Access, and Evaluation --- Organization and Administration --- Diagnosis --- Anti-Infective Agents --- Therapeutic Uses --- Health Care --- Pharmacologic Actions --- Chemical Actions and Uses --- Chemicals and Drugs --- Pharmacy, Therapeutics, & Pharmacology --- Health & Biological Sciences --- Side effects --- Pharmaceutical Epidemiology --- Epidemiology, Pharmaceutical --- Epidemiologies, Pharmaceutical --- Pharmaceutical Epidemiologies --- Drug Reaction Reporting Systems, Adverse --- Product Surveillance, Post-Marketing --- Drug Surveillance, Postmarketing --- Evaluation Studies, Postmarketing --- Postmarketing Product Surveillance --- Drug Surveillances, Postmarketing --- Evaluation Study, Postmarketing --- Post-Marketing Product Surveillance --- Post-Marketing Product Surveillances --- Postmarketing Drug Surveillance --- Postmarketing Drug Surveillances --- Postmarketing Evaluation Studies --- Postmarketing Evaluation Study --- Postmarketing Product Surveillances --- Product Surveillance, Post Marketing --- Product Surveillances, Post-Marketing --- Product Surveillances, Postmarketing --- Studies, Postmarketing Evaluation --- Study, Postmarketing Evaluation --- Surveillance, Post-Marketing Product --- Surveillance, Postmarketing Drug --- Surveillance, Postmarketing Product --- Surveillances, Post-Marketing Product --- Surveillances, Postmarketing Drug --- Surveillances, Postmarketing Product --- Schizonticides --- Agents, Antiprotozoal --- Review, Utilization --- Reviews, Utilization --- Utilization Reviews --- Methodological Studies --- Methodological Study --- Procedures --- Studies, Methodological --- Study, Methodological --- Method --- Procedure --- Anti-Malarials --- Antimalarial Agents --- Antimalarial Drugs --- Agents, Antimalarial --- Anti Malarials --- Drugs, Antimalarial --- Diagnostic Technics and Procedures --- Technics and Procedures, Diagnostic --- Techniques and Procedures, Diagnostic --- Biologic Sciences --- Biological Science --- Science, Biological --- Sciences, Biological --- Biological Sciences --- Life Sciences --- Biologic Science --- Biological Science Discipline --- Discipline, Biological Science --- Disciplines, Biological Science --- Life Science --- Science Discipline, Biological --- Science Disciplines, Biological --- Science, Biologic --- Science, Life --- Sciences, Biologic --- Sciences, Life --- Health Professions --- Health Occupation --- Health Profession --- Occupation, Health --- Occupations, Health --- Profession, Health --- Professions, Health --- Medical Specialities --- Medical Specialties --- Medical Specialty --- Specialities, Medical --- Specialties, Medical --- Specialty, Medical --- Medical Speciality --- Speciality, Medical --- Antiparasitic Drugs --- Antiparasitics --- Parasiticides --- Agents, Antiparasitic --- Drugs, Antiparasitic --- Administration, Pharmacy --- Administrations, Pharmacy --- Pharmacy Administrations --- Quality of Care --- Quality of Healthcare --- Care Qualities --- Care Quality --- Health Care Quality --- Healthcare Quality --- Monitoring, Physiological --- Physiologic Monitoring --- Patient Monitoring --- Monitoring, Patient --- Physiological Monitoring --- Critique --- Evaluation --- Evaluation Indexes --- Evaluation Methodology --- Evaluation Report --- Evaluation Research --- Methodology, Evaluation --- Pre-Post Tests --- Qualitative Evaluation --- Quantitative Evaluation --- Theoretical Effectiveness --- Use-Effectiveness --- Critiques --- Effectiveness, Theoretical --- Evaluation Methodologies --- Evaluation Reports --- Evaluation, Qualitative --- Evaluation, Quantitative --- Evaluations --- Evaluations, Qualitative --- Evaluations, Quantitative --- Indexes, Evaluation --- Methodologies, Evaluation --- Pre Post Tests --- Pre-Post Test --- Qualitative Evaluations --- Quantitative Evaluations --- Report, Evaluation --- Reports, Evaluation --- Research, Evaluation --- Test, Pre-Post --- Tests, Pre-Post --- Use Effectiveness --- Disease --- Environment, Preventive Medicine & Public Health --- Environment, Preventive Medicine and Public Health --- Health, Public --- Health Care Quality Assessment --- Health Care Quality Assurance --- Healthcare Quality Assessment --- Healthcare Quality Assurance --- Quality Assessment, Healthcare --- Quality Assurance, Healthcare --- Quality Assessment, Health Care --- Assessment, Healthcare Quality --- Assessments, Healthcare Quality --- Assurance, Healthcare Quality --- Assurances, Healthcare Quality --- Healthcare Quality Assessments --- Healthcare Quality Assurances --- Quality Assessments, Healthcare --- Quality Assurances, Healthcare --- Utilization, Drug --- Drug Utilizations --- Utilizations, Drug --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Pharmacologies --- Pharmaceutical Preparations --- Chemical Actions --- Actions, Chemical --- Actions, Pharmacologic --- Community-Based Distribution --- Contraceptive Distribution --- Delivery of Healthcare --- Dental Care Delivery --- Distribution, Non-Clinical --- Distribution, Nonclinical --- Distributional Activities --- Healthcare --- Healthcare Delivery --- Healthcare Systems --- Non-Clinical Distribution --- Nonclinical Distribution --- Delivery of Dental Care --- Health Care Delivery --- Health Care Systems --- Activities, Distributional --- Activity, Distributional --- Care, Health --- Community Based Distribution --- Community-Based Distributions --- Contraceptive Distributions --- Deliveries, Healthcare --- Delivery, Dental Care --- Delivery, Health Care --- Delivery, Healthcare --- Distribution, Community-Based --- Distribution, Contraceptive --- Distribution, Non Clinical --- Distributional Activity --- Distributions, Community-Based --- Distributions, Contraceptive --- Distributions, Non-Clinical --- Distributions, Nonclinical --- Health Care System --- Healthcare Deliveries --- Healthcare System --- Non Clinical Distribution --- Non-Clinical Distributions --- Nonclinical Distributions --- System, Health Care --- System, Healthcare --- Systems, Health Care --- Systems, Healthcare --- Therapeutic Effects --- Effects, Therapeutic --- Uses, Therapeutic --- Anti-Microbial Agents --- Antiinfective Agents --- Antimicrobial Agents --- Microbicides --- Agents, Anti-Infective --- Agents, Anti-Microbial --- Agents, Antiinfective --- Agents, Antimicrobial --- Anti Infective Agents --- Anti Microbial Agents --- Antemortem Diagnosis --- Diagnoses and Examinations --- Examinations and Diagnoses --- Postmortem Diagnosis --- Antemortem Diagnoses --- Diagnoses --- Diagnoses, Antemortem --- Diagnoses, Postmortem --- Diagnosis, Antemortem --- Diagnosis, Postmortem --- Postmortem Diagnoses --- Administration and Organization --- Administrative Technics --- Administrative Techniques --- Coordination, Administrative --- Logistics --- Supervision --- Technics, Administrative --- Techniques, Administrative --- Administration --- Administrative Coordination --- Administrative Technic --- Administrative Technique --- Technic, Administrative --- Technique, Administrative --- Healthcare Quality, Access, and Evaluation --- Natural Sciences --- Physical Sciences --- Discipline, Natural Science --- Disciplines, Natural Science --- Natural Science --- Natural Science Discipline --- Physical Science --- Science, Natural --- Science, Physical --- Sciences, Natural --- Sciences, Physical --- Administration, Health Services --- Health Services --- Drug Utilization Evaluation --- Drug-Use Review --- Evaluation, Drug Utilization --- Review, Drug Utilization --- Review, Drug-Use --- Utilization Review, Drug --- Drug Use Review --- Drug Utilization Evaluations --- Drug Utilization Reviews --- Drug-Use Reviews --- Evaluations, Drug Utilization --- Review, Drug Use --- Reviews, Drug Utilization --- Reviews, Drug-Use --- Utilization Evaluation, Drug --- Utilization Evaluations, Drug --- Utilization Reviews, Drug --- Monitoring, Drug --- Therapeutic Drug Monitoring --- Drug Monitoring, Therapeutic --- Monitoring, Therapeutic Drug --- Antimalarial agents --- Drugs --- Therapeutic drug monitoring --- methods --- epidemiology --- pharmacology --- diagnosis --- organization & administration --- Monitoring --- Safety-Based Drug Withdrawals --- Parasites --- Protozoan Infections --- Professional Staff Committees --- Malaria --- Plasmodium --- Antirheumatic Agents --- Sensitivity and Specificity --- Occupations --- Pharmacy Audit --- Audit, Pharmacy --- Pharmacy Audits --- Community Health --- Health, Community --- Preventive Medicine --- Education, Public Health Professional --- Off-Label Use --- Pharmacological and Toxicological Phenomena --- Drug Therapy --- Infection --- Pharmacovigilance --- Antiprotozoal agents --- Patient monitoring --- Chemotherapy --- Analysis --- Testing --- Health Workforce --- Infections --- Anti-Malarial --- Antimalarial --- Antimalarial Agent --- Antimalarial Drug --- Agent, Antimalarial --- Anti Malarial --- Drug, Antimalarial --- Diagnostic Testing --- Testing, Diagnostic --- Antiparasitic --- Social Epidemiology --- Epidemiologies, Social --- Epidemiology, Social --- Social Epidemiologies --- Therapeutic Effect --- Therapeutic Use --- Effect, Therapeutic --- Use, Therapeutic --- Anti-Infective Agent --- Anti-Microbial Agent --- Antimicrobial Agent --- Microbicide --- Agent, Anti-Infective --- Agent, Anti-Microbial --- Agent, Antimicrobial --- Anti Infective Agent --- Anti Microbial Agent --- Diagnose --- Techniques --- Technique

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This Harmonization Project Document presents the conclusions of an IPCS Workshop on Skin Sensitization in Chemical Risk Assessment. The workshop focused on the question of methods for dose-response assessment, to evaluate the relative ability of a chemical to induce sensitization in the skin, and hence inform risk assessment for humans. In addition this publication includes a series of short articles on this topic by leading experts in the field. The conclusions of the workshop cover such aspects as the nature and utility for risk assessment of the data produced by non-animal test methods (suc

Chemicals -- Physiological effect. --- Chemicals -- Risk assessment. --- Health risk assessment. --- Skin tests. --- Toxicology. --- Chemicals --- Hazardous substances --- Skin tests --- Toxicology --- Health risk assessment --- Skin Tests --- Hazardous Substances --- Risk Assessment --- Dermatitis, Contact --- Methods --- Dermatitis --- Immunologic Tests --- Environmental Pollutants --- Skin Diseases, Eczematous --- Investigative Techniques --- Risk --- Diagnostic Techniques and Procedures --- Risk Management --- Epidemiologic Measurements --- Immunologic Techniques --- Probability --- Skin Diseases --- Laboratory Techniques and Procedures --- Organization and Administration --- Public Health --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Diagnosis --- Toxic Actions --- Environment and Public Health --- Statistics as Topic --- Skin and Connective Tissue Diseases --- Chemical Actions and Uses --- Health Services Administration --- Health Care --- Health Care Evaluation Mechanisms --- Diseases --- Chemicals and Drugs --- Epidemiologic Methods --- Quality of Health Care --- Health Care Quality, Access, and Evaluation --- Environmental Engineering --- Civil & Environmental Engineering --- Engineering & Applied Sciences --- Physiological effect --- Risk assessment --- Physiological effect. --- Risk assessment. --- Electronic texts --- Biological and medical sciences. --- Assessment, Health risk --- Health hazard appraisal --- Health hazard assessment --- Health risk appraisal --- HRA (Public health) --- Human risk assessment --- Cutaneous tests --- Chemical compounds --- Compounds, Chemical --- Medicine, Preventive --- Public health --- Environmental health --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Provocation tests (Medicine) --- Chemistry